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Tuesday, July 28, 2020 | History

2 edition of Evaluation of the potential pharmacokinetic interaction between naproxen and zidovudine found in the catalog.

Evaluation of the potential pharmacokinetic interaction between naproxen and zidovudine

L. Huang

Evaluation of the potential pharmacokinetic interaction between naproxen and zidovudine

by L. Huang

  • 178 Want to read
  • 38 Currently reading

Published by Ottawa General Hospital in [Ottawa .
Written in English

    Subjects:
  • Naproxen -- Pharmacokinetics,
  • AZT (Drug) -- Pharmacokinetics

  • Edition Notes

    ContributionsOttawa General Hospital.
    The Physical Object
    Pagination34 p.
    Number of Pages34
    ID Numbers
    Open LibraryOL21441205M

    The aim of this study was to investigate the possibility of a pharmacokinetic drug interaction between ZDV and ddI. 2. The pharmacokinetics of ZDV and ddI were determined in eight patients with AIDS who were randomised to receive ZDV mg orally, ddI mg orally or a combination of ZDV mg plus ddI mg orally on 3 study days separated Cited by: sions, with a washout period of between three and seven days between treatments. Blood samples were taken for pharmacokinetic sampling prior to dosing and post dose at 5, 10, 20, 30 and 40 minutes and 1, , , 2, 3, 6, 9 and 12 hours. In Study 2, subjects were randomised to receive either twice daily (12 hourly) or three times daily (8 Cited by:

    Application of Physiologically-based Pharmacokinetic Modeling to Predict the Pharmacokinetics of Zidovudine and Its Interaction with Fluconazole Using Recombinant UGT2B7 Cl int Inputs and UGT Tissue Scalars. Author(s): Certara USA, Inc., Overlook Center, Suite , Princeton, NJ USA. Didanosine enteric‐coated should be taken on an empty stomach, but the once‐daily combination of indinavir/ritonavir can be taken with food. Because these drugs are frequently included in 1 Cited by: 6.

    Pharmacokinetic interaction between etravirine and lopinavir/ritonavir Monika Schöller-Gyüre,1 Thomas N Kakuda,2 Sophie H Akuma,1 Inge De Clerq,1 Goedele De Smedt,1 Kurt Spittaels,1 Katrien Janssen,1 Veerle Vyncke,1 Richard MW Hoetelmans1 1Tibotec BVBA, Mechelen, Belgium; 2Tibotec Inc., Yardley, PA, USA A Background. Medicating for Nausea. Saul, a medical resident on a hospital rotation, is shadowing a senior doctor on a medical floor. The pair work closely throughout .


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Evaluation of the potential pharmacokinetic interaction between naproxen and zidovudine by L. Huang Download PDF EPUB FB2

Finally, information regarding the clinical pharmacodynamics of zidovudine is presented. This includes possible relationships between zidovudine pharmacokinetics and markers of efficacy and toxicity, and the significance of linking pharmacokinetic and pharmacodynamic by: Pharmacokinetic evaluation of a drug interaction between zidovudine (AZT) and probenecid was conducted in monkeys.

Six animals received 20 mg/kg of AZ Cited by: A potential pharmacokinetic interaction between rifampin (Rimactan, Rifadin) and zidovudine (AZT, Retrovir) was investigated in the population of human immunodeficiency virus-infected patients at our hospital.

The results from four patients who were on long-term (> or = 6 months) combination therapy with zidovudine and rifampin are by: A potential pharmacokinetic interaction between rifampin (Rimactan, Rifadin) and zidovudine (AZT, Retrovir) was investigated in the population of.

Main results: Naproxen had no significant effect (, ANOVA) on the above pharmacokinetic parameters for both zidovudine and its metabolite. Although the power of the study to detect these small differences was Cited by: 9.

To evaluate a potential pharmacokinetic interaction between zidovudine and didanosine, we compared paired samples (alone and in combination with the other agent). A set of two paired measurements was available for zidovudine from 52 patients, and for didanosine from 35 by: Request PDF | Assessment of a Potential Pharmacokinetic Interaction between Nebivolol and Bupropion in Healthy Volunteers | Background/aims: The study aimed at.

Evaluation of the Interaction Between Acetaminophen and Zidovudine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U.S. Federal Government. Thus, the potential pharmacokinetic (PK) interaction between these drugs was evaluated. HBY ( mg Q8H), IDV ( mg Q8H), and ZDV ( mg Q8H) were given to 8 HIV-infected subjects. Serial plasma samples were collected at baseline (ZDV and IDV alone) and day 11 (all 3 drugs) to determine PK parameters using noncompartmental by: 6.

Drug interaction studies have shown that trimethoprim increases the AUC and decreases the renal clearance of lamivudine, although lamivudine does not affect the disposition of trimethoprim.

Other studies have demonstrated no significant interaction between lamivudine and zidovudine or between lamivudine and by: Abstract: This study was conducted to determine the effects of concomitant administration of oral co-trimoxazole ( mg kg 1) and zidovudine (30 mg kg 1) on their respective pharmacokinetics profiles in adult study was conducted in three phases, each separated from the other by a 2-week drug wash-out period.

In the first phase, the animals received zidovudine (30 mg. Zidovudine is metabolized to an inactive 5'‐glucuronide and has a short plasma half‐life requiring frequent dosing.

The present study in six patients without symptoms who were infected with human immunodeficiency virus was undertaken to determine if coadministration of valproic acid which, like zidovudine, is metabolized by glucuronidation, would alter zidovudine by:   Evaluation of the Pharmacokinetic Interaction Between PA and Midazolam The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been. Evaluation of the Drug Interaction Potential Between the Pharmacokinetic Enhancer Cobicistat and Tenofovir Disoproxil Fumarate in Healthy Subjects J M Custodio, W Garner, F Jin, H Cao, M Hepner, B P Kearney, and S Ramanathan.

Gilead Sciences, Inc., Foster City, CA 14th International Workshop on Clinical Pharmacology of HIV Therapy. WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The protease inhibitor (PI) darunavir with low‐dose ritonavir (DRV/r) and the non‐nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine (NVP) are Cited by: Pharmacokinetic Characteristics of Ritonavir, Zidovudine, Lamivudine, and Stavudine in Children with Human Immunodeficiency Virus Infection Courtney V.

Fletcher *, Ram Yogev, Sharon A. Nachman, Andrew Wiznia, Stephen Pelton, Kenneth McIntosh, Kenneth StanleyCited by: 5. A Phase I/II Comparative Pharmacokinetic Study of the Fixed-Dose Combination (FDC) of Zidovudine (ZDV), Lamivudine (3TC), and Nevirapine (NVP) as GPO-Vir Z30 Pediatric Tablets Versus the Individual Liquid Formulations in HIV-Infected Children Greater Than or Equal to Five Months and Less Than 13 Years of Age in ThailandStudy Type: Interventional.

Zidovudine is indicated for the prevention of mother-to-child transmission of HIV-1 infection as part of a regimen that includes oral zidovudine beginning between 14 and 34 weeks gestation, continuous intravenous infusion of zidovudine during labor, and administration of zidovudine syrup to the neonate for the first 6 weeks of life.

A drug interaction can be defined as an interaction between a drug and another substance that prevents the drug from performing as expected. This definition applies to interactions of drugs with other drugs (drug-drug interactions), as well as drugs with. Interaction pharmacocinétique entre la zidovudine et le triméthoprime-sulfaméthoxazole chez les enfants infectés par le VIH-1 OBJECTIF: Évaluer l’effet de l’agent antimicrobien triméthoprime-sulfaméthoxazole (TMP-SMX) sur les caractéris-tiques pharmacocinétiques du médicament antirétroviral zidovudine (ZDV).

However, no pharmacokinetic (e.g., plasma concentrations or intracellular triphosphorylated active metabolite concentrations) or pharmacodynamic (e.g., loss of HIV-1 /HCV virologic suppression) interaction was observed when ribavirin and lamivudine (n = 18), stavudine (n = 10), or zidovudine (n = 6) were coadministered as part of a multi-drug.Pharmacokinetic concepts have been used successfully by pharmacists to individualize patient drug therapy for about a quarter century.

Pharmacokinetic consultant services and individual clinicians routinely provide patient-specific drug-dosing recommendations that increase the efficacy and decrease the toxicity of many medications.treatment”.Zidovudine was combined with Ketoconazole as once daily sustained release matrix tablets for pharmacokinetic boosting of Zidovudine, Ketoconazole inhibits CYP 3A4 enzyme responsible for metabolising Zidovudine hence boosts its plasma concentration, facilitate treatment of fungal infection which are prevalent during AIDS.